Preview

These projects have been announced in papers, preprints, and/or websites. They require significant work in technical development and/or documentation before they will be ready for broad use.

Pufferfish

An open-source full-featured ICU ventilator

Role: maintainer

Why: The COVID-19 pandemic has revealed fundamental structural limitations of the global medical device industry in making medical equipment available to low-resource settings.

What: Pufferfish is a full-featured ICU ventilator designed to be clinically relevant for COVID-19 patients. It is the focus of an ongoing international collaboration between three universities in the US and industrial partners in India, Nepal, Kenya, and the US.

Squid

Simplifying quantitative imaging platform development and deployment

Role: maintainer

Why: Recent progress in microscopy hardware, software, and techniques have enabled new methods for making biological discoveries, yet the cost of hardware makes them accessible only to labs at well-resourced research institutions.

What: Squid is a full suite of modular and open-source hardware and software components and configurations to quickly implement portable facility-grade widefield microscopes and other application-specific imaging capabilities at a fraction of the cost of commercial solutions ($500-$10k vs. $50k-$120k).

Handyfuge

Portable, low-cost, electricity-free centrifugation

Role: lead maintainer

Why: Centrifugation is a crucial step in many diagnostic procedures. But while many open-source designs have been proposed, no design has emerged as a standard for diagnostic use in low-resource settings.

What: Handyfuge is a proof-of-concept of a modular, safety-first design for hand-powered centrifugation. Handyfuge's modularity and compatibility with distributed manufactuing technologies will be used to investigate strategies for platform design and community-building to enable broad exploration of design variations, scale-up, and rapid adaptation and implementation of diagnostic assays for local needs.

Octopi

Open configurable high-throughput imaging platform for infectious disease diagnosis in the field

Role: contributor

Why: Access to quantitative, robust, yet affordable diagnostic tools is necessary to reduce global infectious disease burden.

What: Octopi is a low-cost ($250-$500) automated imaging platform which can quantify malaria parasitemia by scanning 1.5 million red blood cells per minute.

Gravity Machine

Scale-free vertical tracking microscopy

Role: contributor

Why: The behavior and microscale processes associated with freely suspended organisms and sinking particles underlie key ecological processes in the ocean. Mechanistically studying such multiscale processes in the laboratory presents a considerable challenge for microscopy: how to measure single cells at microscale resolution, while allowing them to freely move hundreds of meters in the vertical direction?

What: Gravity Machine is a solution in the form of a scale-free, vertical tracking microscope, based on a "hydrodynamic treadmill" with no bounds for motion along the axis of gravity.

Prototype

These projects are proofs-of-concept and require further development before they will be ready for reuse.

SnapDx

An at-home self-screening kit for COVID-19 testing using saliva

Role: contributor

Why: COVID-19 testing access is still limited for many people due to cost, usability, and other factors.

What: SnapDx is a saliva-based home surveillance monitoring test for SARS-CoV-2 infection.

Open Hardware Site

Template for building websites for open hardware projects

Role: lead maintainer

Why: It can be challenging or costly for people without web development experience (e.g. scientists and engineers) to build user-friendly, maintainable websites for documenting and sharing their open hardware work.

What: This project is developing a Gatsby starter for building freely-hosted static websites for open hardware projects. It is first being developed to help launch websites for various open hardware projects in the Prakash Lab.